Rejuran is a premium biorevitaliser that switches on the skin's own repair processes from within. Unlike conventional hydrating preparations, it works at depth — rebuilding the structure of the skin and returning firmness and a healthy glow. Practitioners call it an injection of health for the skin, because it treats age-related and structural change rather than masking it.
How it works
The active base of Rejuran is polynucleotides (PN) — highly purified DNA fragments derived from salmon milt. Their structure is close to human DNA, which gives full biocompatibility and a minimal risk of rejection.
Once in the skin, polynucleotides form a three-dimensional hydrophilic matrix — a kind of scaffolding — which draws water into the deep dermis and holds it there, stimulates the fibroblasts responsible for collagen and elastin, and gives the tissue physical support, helping it densify and lift. The matrix releases active molecules gradually, which is what makes the result long-lasting.
Clinical effects
Rejuran is particularly effective for
- Dull, dehydrated skin that has lost its tone
- Heightened sensitivity, couperose and rosacea
- Acne scarring and uneven surface
- The first signs of ageing: fine lines, loss of firmness
Compared with conventional injectables
Course and timeline
A course of three treatments at intervals of three to four weeks is recommended for a stable, pronounced result.
The result holds for six to twelve months; a maintenance treatment is carried out roughly every six months.
Contraindications and side effects
- Allergy to fish or salmon — the active components are derived from salmon DNA
- Pregnancy and breastfeeding
- Active inflammation in the injection area
- Autoimmune disease in an active phase
Side effects are rare and limited to mild redness, swelling and occasional bruising at the injection sites, which resolve on their own within three to seven days.
Frequently asked questions
No. Rejuran does not add volume — it rebuilds the structure of the skin from within. The result looks natural, with nothing added on top.
Yes. Rejuran combines well with laser treatments, microcurrent therapy, mesotherapy and botulinum toxin, reinforcing the overall result.
The first improvements appear after one to two weeks. The full effect develops two to three months after the course is completed.
The treatment is carried out under local anaesthesia — either numbing cream or lidocaine included in the preparation.
From six to twelve months, depending on age, skin condition and lifestyle.
Who Rejuran is for
- Those who want to improve the quality of the skin, not simply fill wrinkles
- Those who want a natural, living result with no mask effect
- Those who want to address the cause of ageing rather than its consequence
- Those looking for a durable, sustained effect
Rejuran doesn't add to the skin — it reminds the skin what it once knew how to do. My part is patience; the repair is yours.
Sangwon Lee, M.D., PhD.
Board-Certified Plastic Surgeon
Good skin isn't manufactured, it's persuaded. My role is to give it the right signal and then let it do the rest.
Daeyoung Kim, M.D., PhD.
Board-Certified Plastic Surgeon
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